Most of the time yes.

It’s easier with acoustic elements when thinking kick drum and bass instrument because they are designed to pair well. For live purposes you often need to mix sounds but with electronic elements. The lower frequencies are harder to pair for electronic instruments without external processing.

The kick and the sub bass share similar waveform shapes and noise. I would say there is more work to do when pairing sounds in the lowend with electronic elements. Of course the easiest way to mix the two sounds would be to use your external outputs and mix on a console to do corrections with the EQ.

Considering you only have one device the Analog Four

As I said you should design patches in the context – if you do so normally both elements should take their place naturally when you design…

So design your kick in relation to your bass or vice versa. But then, what we can do inside the box.

First thing comes to my mind here is mixing inside the box, you have 4 tracks and you have volume for each track. That’s a start.
Even without using an EQ and you have a kick track played on track 1 and a sub bass on track 2. If both tracks were set to max volume and one track dropped 50% of max you will begin to notice one track is quieter and you should begin to hear which frequency is masking the other sound from being heard. If you solo each track you like the sound but played together they may not mix well due to masking of a frequency area.

You can also figure out the frequency clash by paying attention to the pattern. What elements clashed frequency wise can be figured out by modifying timing on the sequencer so the elements do not trigger exactly at the same time.
We know on the Elektron sequencer trigs position are not fixed we can drift or SHIFT TRIGS as per say in the manual :
While in GRID RECORDING mode, hold down [FUNC] while pressing the [LEFT] or [RIGHT] arrow keys to perform the trig shift.

You can also make use of the ADSR and soften the attack on one element or the other one. You can reduce the sound so it sustain less longer (if it’s possible)

Then do you have a free filter, one filter who does not do much to the sound design then you can use it as an EQ. Remember a filter is an EQ frequency band area set to be boosted or cut so that band range comes out more for the listener.

Can you sacrifice a track to use it as a Neighbor and then make your sounds clashing working better together with this Neighbor track as per say in the manual :
NEI : This setting is only available in the OSCILLATOR 2 menu. It will route the audio of the multimode filter output of the track preceding the track being edited. This audio can then be affected by the AM, the filters, the overdrive and the amplitude envelope of the track. In this way track 1 can be sent to track 2, track 2 to track 3, track 3 to track 4. For a completely serial routing, turn down the LVL setting of the routed track completely. This setting does nothing on track 1.

You can also figure out the frequency clash by using effects, cut the lows of the effects and enhance some frequencies in the mix it can help. You can enhance a frequency by using the reverb only for frequencies you want to enhance. You have to reduce the original amount of reverb effect to make good use of this trick.

Make good use of what I talked about earlier when designing a Bass with an HP filter instead of the LP with the boost on the Cutoff point, it can help. If you boost on one element and it’s fundamental, try to boost on the other element with some harmonics (better to use a Spectrum analyser for that it’s easier) or reduce the same fundamental.

• Try to see if accent, note slide, swing can help…
• Try to add noise on one of those element…
• Maybe add a pitch envelope on your bass so it stand up a bit more in the mix…
• Don’t forget Harmonics and Overdrive it really can help…

If you can’t get it right inside the box then you will have to make a good use of the separate outputs, overbridge and mixing out of the box.

On a lot of setups drums will be separate from synth sounds so depending on the setup you probably have little device to take care of the mixing or more expensive solution.